Human PERK (EIF2AK3) activation kit by CRISPRa
CAT#: GA106311
EIF2AK3 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2 alpha kinase 3
Find the corresponding CRISPRi Inhibitor Kit
USD 1,657.00
2 Weeks*
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | EIF2AK3 |
Locus ID | 9451 |
Kit Components | GA106311G1, PERK gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106311G2, PERK gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106311G3, PERK gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001313915, NM_004836 |
UniProt ID | Q9NZJ5 |
Synonyms | PEK; PERK; WRS |
Summary | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
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KN214993RB | EIF2AK3 - human gene knockout kit via CRISPR, HDR mediated |
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