PERK (EIF2AK3) Human Gene Knockout Kit (CRISPR)
CAT#: KN214993LP
EIF2AK3 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro RFP-BSD mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
Donor DNA | Luciferase-Puro |
Symbol | PERK |
Locus ID | 9451 |
Components |
KN214993G1, PERK gRNA vector 1 in pCas-Guide CRISPR vector KN214993G2, PERK gRNA vector 2 in pCas-Guide CRISPR vector KN214993LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001313915, NM_004836 |
UniProt ID | Q9NZJ5 |
Synonyms | PEK; PERK; WRS |
Summary | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN214993 | EIF2AK3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN214993BN | EIF2AK3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN214993RB | EIF2AK3 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN414993 | EIF2AK3 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
|
GA106311 | EIF2AK3 CRISPRa kit - CRISPR gene activation of human eukaryotic translation initiation factor 2 alpha kinase 3 |
USD 1,657.00 |
{0} Product Review(s)
Be the first one to submit a review