EDARADD (NM_080738) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC219198L2V

Lenti ORF particles, EDARADD (mGFP-tagged) - Human EDAR-associated death domain (EDARADD), transcript variant B, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: EDARADD
• Synonyms: ECTD11A; ECTD11B; ED3; EDA3
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_080738
• ORF Size: 615 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC219198).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_080738.2
• RefSeq Size: 2891 bp
• RefSeq ORF: 618 bp
• Locus ID: 128178
• UniProt ID: Q8WWZ3
• Cytogenetics: 1q42.3-q43
• Domains: enolase
• Protein Families: Druggable Genome
• MW: 23.5 kDa
• Gene Summary: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]