Riok3 (NM_024182) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR208314L4V

Lenti ORF particles, Riok3 (GFP-tagged) - Mouse RIO kinase 3 (yeast) (Riok3), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Riok3
• Synonyms: 1200013N13Rik; D18Ertd331e; E130306C24Rik; Sudd
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_024182
• ORF Size: 1560 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR208314).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_024182.3, NP_077144.2
• RefSeq Size: 3661 bp
• RefSeq ORF: 1560 bp
• Locus ID: 66878
• UniProt ID: Q9DBU3
• Cytogenetics: 18 6.15 cM
• Gene Summary: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.[UniProtKB/Swiss-Prot Function]