FLG2 (NM_001014342) Human Untagged Clone

CAT#: SC301923

FLG2 (untagged)-Human filaggrin family member 2 (FLG2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FLG2
• Synonyms: IFPS; PSS6
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001014342, the custom clone sequence may differ by one or more nucleotides
  ATGACCGACCTCTTGAGAAGTGTTGTCACCGTAATTGATGTTTTCTACAAATACACCAAG
  CAAGATGGGGAGTGTGGCACACTGAGCAAGGGTGAACTAAAGGAACTTCTGGAGAAAGAG
  CTTCATCCAGTTCTGAAGAACCCAGATGATCCAGACACAGTGGATGTCATCATGCATATG
  CTGGATCGAGATCATGACAGAAGATTGGACTTTACTGAGTTTCTTTTGATGATATTCAAG
  CTGACTATGGCCTGCAACAAGGTCCTCAGCAAAGAATACTGCAAAGCTTCAGGGTCAAAG
  AAGCATAGGCGTGGTCACCGACACCAAGAAGAAGAAAGTGAAACAGAAGAGGATGAAGAG
  GATACACCAGGACATAAATCAGGTTACAGACATTCAAGTTGGAGTGAGGGAGAGGAGCAT
  GGATATAGTTCTGGGCACTCAAGGGGAACTGTGAAATGTAGACATGGGTCCAACTCCAGG
  AGGCTAGGAAGACAAGGTAATTTATCCAGCTCTGGGAACCAAGAGGGATCTCAGAAAAGA
  TACCACAGGTCCAGCTGTGGTCATTCATGGAGTGGTGGCAAAGACAGACATGGTTCCAGC
  TCTGTAGAACTGAGAGAAAGAATAAACAAGTCACACATTAGCCCTTCTAGGGAATCTGGG
  GAGGAGTATGAATCTGGATCTGGATCAAACAGTTGGGAAAGGAAAGGTCATGGTGGTCTG
  TCATGTGGATTGGAGACTAGTGGGCATGAATCAAACTCTACTCAGTCAAGAATTAGAGAA
  CAAAAGCTTGGGTCTAGCTGTTCAGGTTCAGGAGACAGTGGGAGGCGAAGTCATGCATGT
  GGTTATAGCAATTCAAGTGGGTGTGGAAGGCCACAAAATGCTTCAAGTTCTTGTCAGTCA
  CATAGATTTGGAGGGCAAGGAAATCAATTTAGCTATATTCAGTCAGGCTGTCAGTCAGGA
  ATTAAGGGAGGACAAGGCCATGGCTGTGTCTCAGGAGGTCAGCCCTCTGGATGTGGTCAA
  CCTGAGTCTAACCCCTGTAGTCAGTCCTATAGTCAGAGAGGATATGGAGCTAGAGAAAAT
  GGTCAACCACAGAACTGTGGAGGACAATGGAGAACAGGCTCAAGTCAGTCCTCTTGCTGT
  GGACAATATGGGTCTGGAGGTAGCCAGTCTTGTAGTAATGGTCAACATGAATATGGTTCC
  TGTGGCCGCTTTTCAAACTCTTCTAGTTCAAATGAATTTTCCAAATGTGATCAATATGGG
  TCTGGTTCAAGTCAGTCTACTAGCTTTGAACAACATGGAACAGGCTTGAGTCAGTCCTCT
  GGGTTCGAACAACATGTATGTGGCTCAGGTCAAACTTGTGGCCAGCATGAGTCTACATCA
  AGTCAATCCTTGGGCTATGACCAGCATGGGTCTAGCTCAGGTAAGACATCTGGCTTTGGA
  CAACATGGGTCTGGCTCAGGTCAGTCCTCTGGCTTTGGACAATGTGGGTCAGGCTCAGGT
  CAGTCCTCTGGCTTTGGACAGCATGGGTCTGTCTCAGGACAATCCTCTGGTTTTGGACAG
  CATGGGTCTGTCTCAGGACAATCCTCTGGTTTTGGACAACATGAGTCTAGATCACGTCAG
  TCTAGCTATGGCCAACATGGTTCTGGCTCAAGTCAATCATCTGGCTATGGCCAATATGGG
  TCTAGAGAGACATCTGGCTTTGGACAACATGGGTTGGGCTCAGGTCAATCCACTGGCTTT
  GGCCAATATGGATCGGGCTCAGGTCAGTCCTCTGGCTTTGGACAACATGGGTCTGGCTCA
  GGACAATCCTCTGGCTTTGGACAACATGAGTCTAGATCAGGTCAGTCTAGTTATGGCCAA
  CACAGTTCTGGCTCAAGTCAGTCATCTGGCTATGGCCAACATGGGTCTAGACAGACATCT
  GGCTTTGGACAACATGGGTCAGGCTCAAGTCAATCCACTGGCTTTGGCCAATATGGATCA
  GGCTCAGGTCAGTCCTCTGGCTTTGGACAACATGTTTCTGGCTCAGGACAATCCTCTGGT
  TTTGGACAACATGAGTCTAGATCAGGTCATTCTAGCTATGGCCAACATGGTTTTGGCTCA
  AGTCAATCATCTGGCTATGGTCAACATGGGTCAAGTTCAGGACAGACATCTGGATTTGGA
  CAACACGAGTTAAGCTCAGGTCAGTCTTCCAGCTTTGGCCAACATGGATCAGGCTCAGGT
  CAGTCCTCTGGCTTTGGACAACATGGGTCTGGCTCAGGACAATCCTCTGGCTTTGGACAA
  CATGAGTCTAGATCAGGTCAGTCTAGCTATGGCCAACACAGTTCTGGCTCAAGTCAGTCA
  TCTGGCTATGGCCAACATGGGTCTAGACAGACATCTGGCTTTGGACAACATGGGTCAGGC
  TCAAGTCAATCCACTGGCTTTGGCCAATATGGATCAGGCTCAGGTCAGTCCGCTGGCTTT
  GGACAACATGGGTCTGGCTCAGGACAATCCTCTGGCTTTGGACAGCATGAGTCTAGATCA
  CATCAGTCCAGCTATGGCCAACATGGTTCTGGCTCAAGTCAATCATCTGGCTATGGTCAA
  CATGGGTCAAGTTCGGGACAGACATCTGGCTTTGGACAACACAGGTCAAGCTCAGGTCAA
  TACTCTGGCTTTGGACAACATGGATCAGGCTCAGGTCAGTCCAGTGGCTTTGGACAACAT
  GGGACTGGCTCAGGACAATACTCTGGTTTTGGACAACATGAGTCTAGATCACATCAGTCT
  AGCTATGGCCAACATGGTTCTGGCTCAAGTCAGTCATCTGGCTATGGTCAACATGGGTCA
  AGTTCAGGACAGACTTTTGGATTTGGACAACACAGGTCAGGCTCAGGTCAATCCTCTGGC
  TTTGGCCAACATGGATCAGGCTCAGGTCAGTCCTCTGGCTTTGGACAACATGAGTCAGGC
  TCAGGAAAATCCTCTGGCTTTGGACAGCATGAGTCTAGATCAAGTCAGTCTAATTATGGC
  CAACATGGTTCTGGCTCAAGTCAGTCATCTGGCTATGGTCAACATGGGTCTAGTTCAGGA
  CAGACAACTGGCTTTGGACAACACAGGTCAAGCTCAGGCCAATACTCAGGCTTTGGACAA
  CATGGATCAGGCTCAGATCAGTCCTCTGGCTTTGGACAACATGGGACTGGTTCAGGACAA
  TCCTCTGGTTTTGGACAATATGAGTCTAGATCACGTCAGTCTAGCTATGGCCAACATGGT
  TCTGGCTCAAGTCAATCATCTGGCTATGGTCAACATGGGTCAAATTCAGGACAGACATCT
  GGATTTGGACAACACAGGCCAGGCTCAGGTCAGTCCTCTGGCTTTGGCCAATATGGATCG
  GGCTCAGGTCAGTCTTCTGGCTTTGGACAACATGGGTCAGGCACAGGTAAATCCTCTGGC
  TTTGCACAGCATGAGTACAGATCAGGTCAGTCTAGCTATGGCCAACATGGTACTGGCTCC
  AGTCAATCATCTGGCTGTGGCCAACATGAGTCTGGCTCAGGTCCAACCACAAGTTTTGGA
  CAGCATGTGTCTGGCTCAGACAATTTCTCTAGTTCTGGACAACATATATCTGACTCAGGT
  CAGTCCACTGGATTTGGCCAATATGGTTCAGGCTCAGGTCAATCAACTGGCTTGGGCCAG
  GGTGAATCTCAACAAGTAGAGTCAGGATCCACAGTTCATGGGAGACAGGAAACTACTCAT
  GGTCAGACAATAAATACCACTAGACATAGCCAGTCTGGTCAAGGACAATCCACACAGACA
  GGGTCCAGGGTAACTAGAAGACGAAGATCTAGCCAAAGTGAGAACAGTGACAGTGAAGTG
  CACTCAAAGGTCTCACACAGACATTCAGAACACATTCACACACAAGCTGGATCTCACTAC
  CCAAAGTCAGGATCCACAGTTCGCAGAAGACAAGGAACTACTCATGGACAGAGAGGAGAT
  ACCACTAGACATGGCCATTCTGGTCATGGACAGTCTACACAGACAGGTTCCAGAACATCT
  GGAAGACAGAGATTTAGCCACAGTGATGCCACTGACAGTGAAGTGCACTCAGGGGTCTCA
  CATAGACCACACTCACAAGAACAAACTCACAGCCAAGCTGGATCTCAACATGGAGAGTCA
  GAATCCACAGTTCATGAGAGACATGAAACTACTTATGGACAGACAGGAGAGGCCACTGGA
  CATGGCCACTCTGGTCATGGACAGTCCACACAGAGAGGGTCCAGGACAACTGGAAGAAGG
  GGATCTGGCCATAGTGAGTCCAGTGACAGTGAAGTGCACTCAGGGGGCTCACACAGACCA
  CAATCACAAGAACAAACTCATGGCCAAGCCGGATCTCAACATGGAGAGTCAGGATCCACA
  GTTCATGGGAGACACGGAACTACTCATGGACAGACAGGAGATACCACTAGACATGCCCAC
  TATCATCATGGAAAATCCACACAGAGAGGGTCCAGTACAACTGGAAGAAGGGGATCTGGC
  CACAGTGAGTCCAGTGACAGTGAAGTGCACTCAGGGGGCTCGCACACACATTCAGGACAC
  ACTCACGGCCAAAGTGGATCTCAACATGGAGAGTCAGAATCCATAATTCATGACAGACAC
  AGAATTACTCATGGACAGACAGGAGATACCACTAGACATTCCTACTCTGGTCATGAACAA
  ACCACACAGACAGGGTCCAGGACAACTGGAAGACAGAGAACTAGCCACAGTGAGTCCACT
  GACAGTGAAGTGCACTCAGGGGGCTCACACAGACCACACTCACGAGAACACACTTACGGC
  CAAGCCGGATCTCAACATGAAGAGCCAGAATTCACAGTTCATGAGAGACACGGAACTACT
  CATGGACAGATAGGAGATACCACTGGACATTCCCACTCTGGTCATGGACAGTCCACACAG
  AGAGGGTCCAGGACAACTGGAAGACAGAGATCTAGCCACAGTGAGTCCAGTGACAGTGAA
  GTGCACTCAGGGGTCTCACACACACATACAGGACACACTCATGGTCAAGCTGGATCTCAA
  CATGGACAGTCAGAATCCATAGTTCCTGAGAGACATGGAACTACTCATGGACAGACAGGA
  GATACCACTAGACATGCCCACTATCATCATGGATTAACCACACAGACAGGGTCCAGGACT
  ACTGGAAGAAGGGGATCTGGCCACAGTGAGTACAGTGACAGTGAAGGGTACTCAGGAGTC
  TCACATACACATTCAGGACACACTCATGGCCAAGCCAGATCTCAACATGGAGAGTCAGAA
  TCCATAGTTCATGAGAGACATGGAACTATACATGGACAGACAGGCGATACCACCAGACAT
  GCCCACTCTGGTCATGGACAGTCCACACAGACAGGGTCCAGGACCACTGGAAGAAGGTCA
  TCTGGCCACAGTGAGTACAGTGACAGTGAAGGGCACTCAGGGTTCTCACAAAGACCACAC
  TCACGAGGACACACTCACGGCCAGGCTGGATCTCAACATGGAGAGTCAGAATCCATAGTT
  GACGAGAGACATGGAACTACTCATGGACAGACAGGAGATACCAGTGGACATTCTCAATCT
  GGTCATGGACAGTCCACACAGTCAGGATCCAGTACAACTGGAAGAAGGAGATCTGGCCAC
  AGTGAGTCCAGTGACAGTGAAGTGCACTCAGGGGGCTCACATACACATTCAGGACACACA
  CACAGCCAAGCCAGGTCTCAACATGGAGAGTCAGAATCCACAGTTCACAAGAGACACCAA
  ACTACTCATGGACAGACAGGAGATACCACTGAACATGGCCACCCTAGTCATGGACAAACC
  ATACAGACAGGGTCCAGGACAACTGGAAGAAGGGGATCTGGCCACAGTGAGTACAGTGAC
  AGTGAAGGGCCCTCAGGGGTCTCACACACACATTCAGGACACACTCACGGTCAAGCTGGA
  TCTCACTATCCAGAGTCAGGATCCTCAGTTCATGAGAGACACGGAACTACTCATGGACAA
  ACAGCAGATACCACTAGACATGGCCACTCTGGTCATGGACAGTCCACACAGAGAGGGTCC
  AGGACAACTGGAAGAAGGGCATCTGGCCACAGTGAGTACAGTGACAGTGAAGGGCACTCA
  GGGGTCTCACACACACATTCAGGACACGCTCATGGCCAAGCCGGATCTCAACATGGAGAG
  TCAGGATCCTCAGTTCATGAGAGACACGGAACTACTCATGGACAGACAGGAGATACCACT
  AGACATGCTCACTCTGGTCATGGACAGTCCACACAGAGAGGGTCAAGGACAGCTGGAAGA
  AGGGGATCTGGCCACAGTGAGTCCAGTGACAGTGAAGTGCACTCAGGGGTCTCACACACA
  CATTCAGGACACACTTATGGCCAAGCCAGATCTCAACATGGAGAGTCAGGATCTGCCATT
  CACGGGAGACAGGGAACTATACATGGACAGACAGGAGATACCACTAGACATGGCCAGTCT
  GGTCATGGACAGTCCACACAGACAGGTTCCAGGACAACTGGAAGACAAAGATCTAGTCAC
  AGTGAGTCCAGTGATAGTGAAGTGCACTCAGAGGCCTCACCCACACATTCAGGACACACT
  CACAGCCAAGCCGGATCTCGACATGGACAGTCAGGATCCTCAGGTCATGGGAGACAGGGA
  ACTACTCATGGACAGACAGGAGATACCACTAGACATGCCCACTATGGTTATGGACAATCC
  ACACAGAGAGGGTCCAGGACAACTGGAAGAAGGGGATCTGGCCACAGTGAGTCCAGTGAC
  AGTGAAGTGCACTCATGGGGCTCACACACACATTCAGGACACATTCAGGGCCAAGCTGGA
  TCTCAACAAAGACAGCCAGGATCCACAGTTCATGGGAGACTGGAAACTACTCATGGACAG
  ACAGGAGATACCACTAGACATGGCCATTCTGGTTATGGACAATCCACACAGACAGGTTCC
  AGATCTAGTAGAGCAAGTCATTTTCAGTCACATAGTAGTGAAAGGCAAAGGCATGGATCA
  AGTCAGGTTTGGAAACATGGCAGCTATGGACCTGCAGAATATGACTATGGGCACACTGGG
  TATGGGCCTTCTGGTGGCAGCAGAAAAAGCATCAGTAATTCTCACCTTTCATGGTCAACA
  GACAGCACTGCAAACAAGCAACTGTCTAGACATTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_001014342
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001014342.1, NP_001014364.1
• RefSeq Size: 9147 bp
• RefSeq ORF: 7176 bp
• Locus ID: 388698
• UniProt ID: Q5D862
• Cytogenetics: 1q21.3
• Gene Summary: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020]