ZRANB3 (NM_001286569) Human Tagged ORF Clone
CAT#: RG239134
- TrueORF®
ZRANB3 (tGFP-tagged) - Human zinc finger, RAN-binding domain containing 3 (ZRANB3), transcript variant 3
ORF Plasmid: DDK
"NM_001286569" in other vectors (2)
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | TurboGFP |
Symbol | ZRANB3 |
Synonyms | 4933425L19Rik; AH2 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RG239134 representing NM_001286569.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTGGGGAATGTTGAATCGCAAGGCTCAAGTTACAGGGAGCACACTGAACGGTAGGAAAGAAAAAATT CAGGCTGAGGAAGGTGATAAGGAAAAATGGGATTTCCTGCAGTTTGCTGAAGCTTGGACTCCAAATGAC AGTTCTGAAGAGTTAAGGAAGGAAGCTTTGTTCACTCACTTCGAAAAAGAAAAACAGCATGATATTCGA TCATTTTTTGTACCACAACCTAAAAAAAGACAGTTGATGACCTCCTGTGACGAATCAAAGAGATTCCGG GAGGAAAATACTGTAGTGTCATCAGACCCTACAAAAACAGCTGCAAGAGATATCATCGATTATGAAAGT GATGTTGAACCTGAAACGAAAAGATTGAAATTGGCTGCCTCGGAAGACCACTGCAGTCCGTCGGAAGAG ACACCATCCCAGTCCAAGCAAATCCGAACTCCACTCGTGGAAAGTGTACAGGAGGCCAAGGCCCAGTTA ACCACCCCAGCCTTTCCTGTAGAGGGCTGGCAATGTAGTCTCTGCACCTATATCAATAATTCAGAGTTA CCTTATTGTGAAATGTGTGAGACTCCTCAAGGCAGTGCTGTTATGCAAATAGATAGCCTCAACCATATC CAGGATAAAAACGAGAAGGATGATTCTCAGAAAGACACCTCCAAAAAGGTTCAAACTATCTCAGACTGT GAAAAACAAGCCCTTGCACAGTCAGAACCTGGCCAGTTGGCTGACAGCAAGGAAGAAACACCAAAAATT GAGAAAGAAGACGGACTTACATCCCAGCCAGGTAATGAACAGTGGAAGAGTTCAGACACTTTGCCAGTG TATGACACCTTAATGTTCTGTGCAAGTAGGAATACTGACCGGATTCACATCTATACTAAGGATGGAAAA CAGATGAGCTGTAATTTCATTCCTCTGGATATAAAATTAGACCTTTGGGAAGATTTACCAGCAAGCTTT CAGCTGAAACAATATCGCTCACTGATTTTGAGATTTGTTCGAGAATGGAGTAGTCTAACTGCCATGAAG CAAAGGATAATCAGGAAAAGTGGACAGCTATTCTGTAGCCCAATTCTTGCTTTGGAAGAGATCACAAAG CAACAAACCAAACAAAATTGCACCAAAAGATACATAACCAAAGAAGATGTTGCCGTAGCCTCAATGGAC AAAGTGAAGAATGTTGGGGGCCATGTCCGTCTGATCACAAAGGAGTCCAGGCCACGGGATCCTTTCACA AAAAAACTTCTTGAAGATGGAGCCTGTGTCCCATTTCTAAATCCATACACAGTCCAGGCAGATCTCACT GTGAAGCCCTCTACATCCAAAGGCTATTTGCAAGCTGTGGATAATGAAGGAAATCCACTTTGCCTTCGC TGTCAGCAACCCACTTGCCAGACTAAGCAAGCATGTAAAGCGAACTCTTGGGATTCACGGTTTTGCTCT CTGAAATGTCAGGAAGAGTTTTGGATTCGATCTAATAACAGTTACCTGAGAGCCAAAGTATTTGAAACT GAACATGGTGTGTGTCAGCTCTGTAATGTGAACGCACAAGAACTCTTTTTACGTCTGAGAGATGCCCCT AAAAGTCAGAGGAAGAATCTTCTGTATGCTACCTGGACTTCAAAGCTCCCATTAGAACAGCTAAATGAA ATGATAAGAAACCCAGGGGAAGGACATTTCTGGCAGGTGGATCACATCAAGCCAGTGTATGGGGGAGGA GGACAGTGTTCCCTGGACAACCTGCAGACTCTCTGCACAGTCTGTCACAAAGAGAGAACTGCCAGACAA GCTAAGGAAAGAAGCCAGGTGAGAAGACAATCTCTAGCATCAAAGCATGGATCAGACATCACACGATTT TTGGTAAAGAAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG239134
Blue=ORF Red=Cloning site Green=Tag(s) MWGMLNRKAQVTGSTLNGRKEKIQAEEGDKEKWDFLQFAEAWTPNDSSEELRKEALFTHFEKEKQHDIR SFFVPQPKKRQLMTSCDESKRFREENTVVSSDPTKTAARDIIDYESDVEPETKRLKLAASEDHCSPSEE TPSQSKQIRTPLVESVQEAKAQLTTPAFPVEGWQCSLCTYINNSELPYCEMCETPQGSAVMQIDSLNHI QDKNEKDDSQKDTSKKVQTISDCEKQALAQSEPGQLADSKEETPKIEKEDGLTSQPGNEQWKSSDTLPV YDTLMFCASRNTDRIHIYTKDGKQMSCNFIPLDIKLDLWEDLPASFQLKQYRSLILRFVREWSSLTAMK QRIIRKSGQLFCSPILALEEITKQQTKQNCTKRYITKEDVAVASMDKVKNVGGHVRLITKESRPRDPFT KKLLEDGACVPFLNPYTVQADLTVKPSTSKGYLQAVDNEGNPLCLRCQQPTCQTKQACKANSWDSRFCS LKCQEEFWIRSNNSYLRAKVFETEHGVCQLCNVNAQELFLRLRDAPKSQRKNLLYATWTSKLPLEQLNE MIRNPGEGHFWQVDHIKPVYGGGGQCSLDNLQTLCTVCHKERTARQAKERSQVRRQSLASKHGSDITRF LVKK TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001286569 |
ORF Size | 1875 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reference Data | |
RefSeq | NM_001286569.1, NP_001273498.1 |
RefSeq Size | 6958 bp |
RefSeq ORF | 1878 bp |
Locus ID | 84083 |
Cytogenetics | 2q21.3 |
Protein Families | Druggable Genome |
MW | 72 kDa |
Gene Summary | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558).[UniProtKB/Swiss-Prot Function] |
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