CCN1 (CYR61) Human Gene Knockout Kit (CRISPR)

CAT#: KN203492RB

CYR61 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: CCN1
• Locus ID: 3491
• Components:

  KN203492G1, CCN1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN203492G2, CCN1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN203492RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001554
• UniProt ID: O00622
• Synonyms: CCN1; GIG1; IGFBP10
• Summary: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]