C2 (NM_000063) Human Untagged Clone

CAT#: SC115664

C2 (untagged)-Human complement component 2 (C2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: C2
• Synonyms: ARMD14; CO2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC115664 sequence for NM_000063 edited (data generated by NextGen Sequencing)
  ATGGGCCCACTGATGGTTCTTTTTTGCCTGCTGTTCCTGTACCCAGGTCTGGCAGACTCG
  GCTCCCTCCTGCCCTCAGAACGTGAATATCTCGGGTGGCACCTTCACCCTCAGCCATGGC
  TGGGCTCCTGGGAGCCTTCTCACCTACTCCTGCCCCCAGGGCCTGTACCCATCCCCAGCA
  TCACGGCTGTGCAAGAGCAGCGGACAGTGGCAGACCCCAGGAGCCACCCGGTCTCTGTCT
  AAGGCGGTCTGCAAACCTGTGCGCTGTCCAGCCCCTGTCTCCTTTGAGAATGGCATTTAT
  ACCCCACGGCTGGGGTCCTATCCCGTGGGTGGCAATGTGAGCTTCGAGTGTGAGGATGGC
  TTCATATTGCGGGGCTCGCCTGTGCGTCAGTGTCGCCCCAACGGCATGTGGGATGGAGAA
  ACAGCTGTGTGTGATAATGGGGCTGGCCACTGCCCCAACCCAGGCATTTCACTGGGCGCA
  GTGCGGACAGGCTTCCGCTTTGGTCATGGGGACAAGGTCCGCTATCGCTGCTCCTCGAAT
  CTTGTGCTCACGGGGTCTTCGGAGCGGGAGTGCCAGGGCAACGGGGTCTGGAGTGGAACG
  GAGCCCATCTGCCGCCAACCCTACTCTTATGACTTCCCTGAGGACGTGGCCCCTGCCCTG
  GGCACTTCCTTCTCCCACATGCTTGGGGCCACCAATCCCACCCAGAAGACAAAGGAAAGC
  CTGGGCCGTAAAATCCAAATCCAGCGCTCTGGTCATCTGAACCTCTACCTGCTCCTGGAC
  TGTTCGCAGAGTGTGTCGGAAAATGACTTTCTCATCTTCAAGGAGAGCGCCTCCCTCATG
  GTGGACAGGATCTTCAGCTTTGAGATCAATGTGAGCGTTGCCATTATCACCTTTGCCTCA
  GAGCCCAAAGTCCTCATGTCTGTCCTGAACGACAACTCCCGGGATATGACTGAGGTGATC
  AGCAGCCTGGAAAATGCCAACTATAAAGATCATGAAAATGGAACTGGGACTAACACCTAT
  GCGGCCTTAAACAGTGTCTATCTCATGATGAACAACCAAATGCGACTCCTCGGCATGGAA
  ACGATGGCCTGGCAGGAAATCCGACATGCCATCATCCTTCTGACAGATGGAAAGTCCAAT
  ATGGGTGGCTCTCCCAAGACAGCTGTTGACCATATCAGAGAGATCCTGAACATCAACCAG
  AAGAGGAATGACTATCTGGACATCTATGCCATCGGGGTGGGCAAGCTGGATGTGGACTGG
  AGAGAACTGAATGAGCTAGGGTCCAAGAAGGATGGTGAGAGGCATGCCTTCATTCTGCAG
  GACACAAAGGCTCTGCACCAGGTCTTTGAACATATGCTGGATGTCTCCAAGCTCACAGAC
  ACCATCTGCGGGGTGGGGAACATGTCAGCAAACGCCTCTGACCAGGAGAGGACACCCTGG
  CATGTCACTATTAAGCCCAAGAGCCAAGAGACCTGCCGGGGGGCCCTCATCTCCGACCAA
  TGGGTCCTGACAGCAGCTCATTGCTTCCGCGATGGCAACGACCACTCCCTGTGGAGGGTC
  AATGTGGGAGACCCCAAATCCCAGTGGGGCAAAGAATTCCTTATTGAGAAGGCGGTGATC
  TCCCCAGGGTTTGATGTCTTTGCCAAAAAGAACCAGGGAATCCTGGAGTTCTATGGTGAT
  GACATAGCTCTGCTGAAGCTGGCCCAGAAAGTAAAGATGTCCACCCATGCCAGGCCCATC
  TGCCTTCCCTGCACGATGGAGGCCAATCTGGCTCTGCGGAGACCTCAAGGCAGCACCTGT
  AGGGACCATGAGAATGAACTGCTGAACAAACAGAGTGTTCCTGCTCATTTTGTCGCCTTG
  AATGGGAGCAAACTGAACATTAACCTTAAGATGGGAGTGGAGTGGACAAGCTGTGCCGAG
  GTTGTCTCCCAAGAAAAAACCATGTTCCCCAACTTGACAGATGTCAGGGAGGTGGTGACA
  GACCAGTTCCTATGCAGTGGGACCCAGGAGGATGAGAGTCCCTGCAAGGGAGAATCTGGG
  GGAGCAGTTTTCCTTGAGCGGAGATTCAGGTTTTTTCAGGTGGGTCTGGTGAGCTGGGGT
  CTTTACAACCCCTGCCTTGGCTCTGCTGACAAAAACTCCCGCAAAAGGGCCCCTCGTAGC
  AAGGTCCCGCCGCCACGAGACTTTCACATCAATCTCTTCCGCATGCAGCCCTGGCTGAGG
  CAGCACCTGGGGGATGTCCTGAATTTTTTACCCCTCTAG
  
  Clone variation with respect to NM_000063.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000063 unedited
  NGTTCGAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGCTAACANAAG
  ACCATCCCCCTTGCCACTCCCTGGTTTTTCTTCTCTGGCAGCAATGAAGCAGCTGCTGAC
  CCAGCTCTAGTTTTCGGGAAGTCAGATGACCTTTTCCCTCCCGCGGCTCTCTACCTCTCG
  CCGCCCCTAGGGAGGACACCATGGGCCCACTGATGGTTCTTTTTTGCCTGCTGTTCCTGT
  ACCCAGGTCTGGCAGACTCGGCTCCCTCCTGCCCTCAGAACGTGAATATCTCGGGTGGCA
  CCTTCACCCTCAGCCATGGCTGGGCTCCTGGGAGCCTTCTCACCTACTCCTGCCCCCAGG
  GCCTGTACCCATCCCCAGCATCACGGCTGTGCAAGAGCAGCGGACAGTGGCAGACCCCAG
  GAGCCACCCGGTCTCTGTCTAAGGCGGTCTGCAAACCTGTGCGCTGTCCAGCCCCTGTCT
  CCTTTGAGAATGGCATTTATACCCCACGGCTGGGGTCCTATCCCGTGGGTGGCAATGTGA
  GCTTCGAGTGTGAGGATGGCTTCATATTGCGGGGCTCGCCTGTGCGTCAGTGTCGCCCCA
  ACGGCATGTGGGATGGAGAAACAGCTGTGTGTGATAATGGGGCTGGCCACTGCCCCAACC
  CAGGCATTTCACTGGGCGCAGTGCGGACAGGCTTCCGCTNTGGTCATGGGGACAAGGTCC
  GCTATCGCTGCTCCTCGAATCTTGTGCTCACGGNGTCTTCGGAGCGGNAGTGCCAGGGCA
  ACGGGGTCTGGAGTGGAACGGAGCCCATCTGCCGNCAACCCTACTCTTATGACTTNCCTG
  NAGGACGTGGGCCCTGNCCTGGGCACTTNCTTCTCCCACATGCTGGNNGCCACCATCCCA
  CCCAAAGACAAAGGAAAGCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000063 unedited
  CCCCCATTCCTTGCCCGCGGCCGCAATCTACAGTCGACTTTTTTTTTTTTTTTTTTTGTG
  GAAACCATTGATTTTTATTAATTTCATAACTGGGAAATTCCATGTGAAAGTGAAACAAGC
  ATGAGTCAAGTCAACCAGGGAAGGAATCTGGGGACAGGCCACGGAGCGGGAGGTGGGGCA
  GCGAGGCAGTCCTGCTGGTAGGAGCCCTGAGGATTTCCCAGCTTGTGTGCGCTGCCTCTG
  GCATCCTAGAGACCCGGATTTACTCAGCTAGGAGAGAGGATGGATCACAGGGTCTAAGGG
  TGGCCATTCAGAGGTAGAAGATGGAGGGGCGGCAGATTCTGGCAGGGCAGCAGAGGGCTC
  AGTGGCCATGGCTAGAGGGGTAAAAAATTCAGGACATCCCCCAGGTGCTGCCTCAGCCAG
  GGCTGCATGCGGAAGAGATTGATGTGAAAGTCTCGTGGCGGCGGGACCTTGCTACGAGGG
  GCCCTTTTGCGGGAGTTTTTGTCAGCAGAGCCCAGGCAGGGGTTGTAAAGACCCCAGCTC
  ACCAGACCCACCTGACAAAACCTGAATCTCCGATCAAGGAAAACTGCTCCCCCAGATTCT
  CCCTTGCAGGGACTCTCATCCTCCTGGGTCCCACTGCATAGGAACTGGCCCGCCACCACC
  TCCCTGACATCTGTCAAGCTGGGCGAACACGGCCTCTTTTTTTTCTAGACTCCCTCGGCC
  CAAGCTTCGTCACCATCCTTCCCCTCCTCAGGGCCCCGCCTACACCTTGTCCCAATTCCG
  CCCCCTCCCCTCCATCCCTACATCTCTTCCCTCACACACCCCCTTCATCCCCCACCCCTC
  CTCCCCCCCTCTCCCCGCTCATCACTGCCCCTTCCCCTGTCGCCGCTCTCTCCCCCCCCC
  CTCCGCCGCCCCCACCCCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000063
• Insert Size: 2740 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000063.3, NP_000054.2
• RefSeq Size: 2609 bp
• RefSeq ORF: 2259 bp
• Locus ID: 717
• UniProt ID: P06681
• Cytogenetics: 6p21.33
• Domains: CCP, Tryp_SPc, VWA
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus
• Gene Summary: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) encodes the longest isoform (1).