IL2 Receptor alpha (IL2RA) Human Recombinant Protein

CAT#: TP724800

Biotinylated Recombinant Human IL-2RA/CD25 (C-Avi&His)

Specifications

Product Data

• Species: Human
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Glu22-Gln240
• Tag: C-Avi&His
• Buffer: Supplied as a 0.2 um filtered solution of PBS, pH7.4
• Note: Biotinylated recombinant Human Interleukin-2 Receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Glu22-Gln240 is expressed with a Avi and 6His tag at the C-terminus.
• Storage: Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 3559
• UniProt ID: P01589
• Synonyms: Interleukin-2 receptor subunit alpha;CD25;p55;TAC antigen;IL2-RA;IL-2R subunit alpha;IL-2-RA;IL2RA;IL-2 receptor subunit alpha
• Summary: Interleukin-2 receptor subunit alpha (IL2RA) is a single-pass type I membrane glycoprotein, contains 2 Sushi (CCP/SCR) domains. IL2RA is expressed on activated T cells and regulatory T cells, and can bind IL2 with low affinity by itself. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. While homodimeric alpha chains (IL2RA) result in low-affinity receptor, homodimeric beta (IL2RB) chains produce a medium-affinity receptor. CD25 has been previously regarded as an activation marker on dendritic cells. Although both murine and human dendritic cells can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Jak-STAT signaling pathway