PIGR Human Recombinant Protein

CAT#: TP724645

Biotinylated Recombinant Human Polymeric Immunoglobulin Receptor/PIgR (C-His)

Specifications

Product Data

• Species: Human
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  K19-R638
• Tag: C-8His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Note: Biotinylated Recombinant Human Polymeric Immunoglobulin Receptor is produced by Human 293 Cells. The target gene encoding K19-R638 is expressed with a 8His tag at the C terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 5284
• UniProt ID: P01833
• Synonyms: Polymeric Immunoglobulin Receptor; PIgR; Poly-Ig Receptor; Hepatocellular Carcinoma- Associated Protein TB6; PIGR
• Summary: Polymeric Immunoglobulin Receptor (pIgR) is a type I transmembrane glycoprotein. pIgR is expressed by secretory epithelial cells with five Ig-like domains in the extracellular region, and transfer to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs and separates the extracellular (known as the secretory component) from the transmembrane segment.
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane