PRPS2 Human Recombinant Protein

CAT#: TP724596

Recombinant Human Ribose-Phosphate Pyrophosphokinase 2/PRPS2 (C-His)

Specifications

Product Data

• Species: Human
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Leu318
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.4
• Note: Recombinant Human PRPS2 is produced by E. coli. The target gene encoding Met1-Leu318 is expressed with a 6His tag at the C terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 5634
• UniProt ID: P11908
• Synonyms: Ribose-Phosphate Pyrophosphokinase 2; PPRibP; Phosphoribosyl Pyrophosphate Synthase II; PRS-II; PRPS2
• Summary: Ribose-Phosphate Pyrophosphokinase 2 (PRPS2) is a phosphoribosyl pyrophosphate synthetase that belongs to the ribose-phosphate pyrophosphokinase family. PRPS2 is a homodimer. The active form could be a hexamer composed of three homodimers. PRPS2 catalyzes the synthesis of phosphoribosyl pyrophosphate (PRPP) that is essential for nucleotide synthesis. PRPS2 catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. In addition, PRPS2 plays a central role in the synthesis of purines and pyrimidines. Thus, dysfunction of the enzyme would undermine purine metabolism.
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pentose phosphate pathway, Purine metabolism