Txnip Mouse Gene Knockout Kit (CRISPR)
CAT#: KN318517RB
Txnip - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | Txnip |
Locus ID | 56338 |
Components |
KN318517G1, Txnip gRNA vector 1 in pCas-Guide CRISPR vector KN318517G2, Txnip gRNA vector 2 in pCas-Guide CRISPR vector KN318517RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001009935, NM_023719 |
UniProt ID | Q8BG60 |
Synonyms | 1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1 |
Summary | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN318517 | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN318517BN | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN318517LP | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN518517 | Txnip - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
|
GA205916 | Txnip CRISPRa kit - CRISPR gene activation of mouse thioredoxin interacting protein |
USD 1,657.00 |
{0} Product Review(s)
Be the first one to submit a review