Mouse Txnip activation kit by CRISPRa
CAT#: GA205916
Txnip CRISPRa kit - CRISPR gene activation of mouse thioredoxin interacting protein
Find the corresponding CRISPRi Inhibitor Kit
USD 1,657.00
2 Weeks*
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Txnip |
Locus ID | 56338 |
Kit Components | GA205916G1, Txnip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205916G2, Txnip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205916G3, Txnip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001009935, NM_023719 |
UniProt ID | Q8BG60 |
Synonyms | 1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1 |
Summary | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.[UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN318517 | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN318517BN | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN318517LP | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN318517RB | Txnip - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN518517 | Txnip - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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