Gpc1 Mouse Gene Knockout Kit (CRISPR)
CAT#: KN307154BN
Gpc1 - mouse gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro RFP-BSD
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control |
Donor DNA | mBFP-Neo |
Symbol | Gpc1 |
Locus ID | 14733 |
Components |
KN307154G1, Gpc1 gRNA vector 1 in pCas-Guide CRISPR vector KN307154G2, Gpc1 gRNA vector 2 in pCas-Guide CRISPR vector KN307154BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_016696 |
UniProt ID | Q9QZF2 |
Synonyms | AI462976 |
Summary | Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions.[UniProtKB/Swiss-Prot Function] |
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Other Versions
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KN307154 | Gpc1 - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN307154LP | Gpc1 - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN307154RB | Gpc1 - mouse gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN507154 | Gpc1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
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