YAP1 Human Gene Knockout Kit (CRISPR)
CAT#: KN214393RB
YAP1 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
4 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | YAP1 |
Locus ID | 10413 |
Components |
KN214393G1, YAP1 gRNA vector 1 in pCas-Guide CRISPR vector KN214393G2, YAP1 gRNA vector 2 in pCas-Guide CRISPR vector KN214393RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001130145, NM_001195044, NM_001195045, NM_001282097, NM_001282098, NM_001282099, NM_001282100, NM_001282101, NM_006106 |
UniProt ID | P46937 |
Synonyms | COB1; YAP; YAP2; YAP65; YKI |
Summary | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013] |
Documents
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Resources
Other Versions
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KN214393 | YAP1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN214393BN | YAP1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN214393LP | YAP1 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
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KN414393 | YAP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
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GA107099 | YAP1 CRISPRa kit - CRISPR gene activation of human Yes associated protein 1 |
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