DUSP6 Human Gene Knockout Kit (CRISPR)
CAT#: KN206765RB
DUSP6 - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
USD 1,657.00
2 Weeks*
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | DUSP6 |
Locus ID | 1848 |
Components |
KN206765G1, DUSP6 gRNA vector 1 in pCas-Guide CRISPR vector KN206765G2, DUSP6 gRNA vector 2 in pCas-Guide CRISPR vector KN206765RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_001946, NM_022652 |
UniProt ID | Q16828 |
Synonyms | HH19; MKP3; PYST1 |
Summary | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN206765 | DUSP6 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN206765BN | DUSP6 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN206765LP | DUSP6 - human gene knockout kit via CRISPR, HDR mediated |
USD 1,657.00 |
|
KN406765 | DUSP6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
USD 1,657.00 |
|
GA101298 | DUSP6 CRISPRa kit - CRISPR gene activation of human dual specificity phosphatase 6 |
USD 1,657.00 |
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