ZNFN1A2 (IKZF2) Human Gene Knockout Kit (CRISPR)

CAT#: KN206483BN

IKZF2 - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: ZNFN1A2
• Locus ID: 22807
• Components:

  KN206483G1, ZNFN1A2 gRNA vector 1 in pCas-Guide CRISPR vector

  KN206483G2, ZNFN1A2 gRNA vector 2 in pCas-Guide CRISPR vector

  KN206483BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001079526, NM_016260
• UniProt ID: Q9UKS7
• Synonyms: ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
• Summary: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]