Prostaglandin dehydrogenase 1 (HPGD) Human Gene Knockout Kit (CRISPR)

CAT#: KN204160RB

HPGD - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
• Donor DNA: RFP-BSD
• Symbol: Prostaglandin dehydrogenase 1
• Locus ID: 3248
• Components:

  KN204160G1, Prostaglandin dehydrogenase 1 gRNA vector 1 in pCas-Guide CRISPR vector

  KN204160G2, Prostaglandin dehydrogenase 1 gRNA vector 2 in pCas-Guide CRISPR vector

  KN204160RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_000860, NM_001145816, NM_001256301, NM_001256305, NM_001256306, NM_001256307, NR_027332, NM_001363574
• UniProt ID: P15428
• Synonyms: 15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1
• Summary: This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]