Mouse Dnajc3 activation kit by CRISPRa

CAT#: GA218727

Dnajc3 CRISPRa kit - CRISPR gene activation of mouse DnaJ heat shock protein family (Hsp40) member C3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Dnajc3
• Locus ID: 100037258
• Kit Components:

  GA218727G1, Dnajc3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA218727G2, Dnajc3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA218727G3, Dnajc3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008929
• UniProt ID: Q91YW3
• Synonyms: AA408985; AU067833; Dnajc3a; Dnajc3b; mp58; p58; p58IPK; Prkri
• Summary: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (PubMed:25329545). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity).[UniProtKB/Swiss-Prot Function]