Mouse Daam1 activation kit by CRISPRa

CAT#: GA212893

Daam1 CRISPRa kit - CRISPR gene activation of mouse dishevelled associated activator of morphogenesis 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Daam1
• Locus ID: 208846
• Kit Components:

  GA212893G1, Daam1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA212893G2, Daam1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA212893G3, Daam1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286452, NM_026102, NM_172464
• UniProt ID: Q8BPM0
• Summary: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (PubMed:26526197).[UniProtKB/Swiss-Prot Function]