Mouse Klf17 activation kit by CRISPRa

CAT#: GA210336

Klf17 CRISPRa kit - CRISPR gene activation of mouse Kruppel-like factor 17

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Klf17
• Locus ID: 75753
• Kit Components:

  GA210336G1, Klf17 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210336G2, Klf17 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210336G3, Klf17 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_029416
• UniProt ID: Q8CFA7
• Synonyms: 7420700M05Rik; AA420409; AU043468; C85123; D4Ertd561e; Gzf; Zfp393
• Summary: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.[UniProtKB/Swiss-Prot Function]