Mouse Dnajb6 activation kit by CRISPRa

CAT#: GA204827

Dnajb6 CRISPRa kit - CRISPR gene activation of mouse DnaJ heat shock protein family (Hsp40) member B6

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Dnajb6
• Locus ID: 23950
• Kit Components:

  GA204827G1, Dnajb6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204827G2, Dnajb6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204827G3, Dnajb6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037940, NM_001037941, NM_001127367, NM_011847, NM_001359198, NR_152863
• UniProt ID: O54946
• Synonyms: mDj4; Mrj
• Summary: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity).[UniProtKB/Swiss-Prot Function]