Mouse Tnfrsf10b activation kit by CRISPRa

CAT#: GA204389

Tnfrsf10b CRISPRa kit - CRISPR gene activation of mouse tumor necrosis factor receptor superfamily, member 10b

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Tnfrsf10b
• Locus ID: 21933
• Kit Components:

  GA204389G1, Tnfrsf10b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204389G2, Tnfrsf10b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204389G3, Tnfrsf10b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020275
• UniProt ID: Q9QZM4
• Synonyms: DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB
• Summary: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[UniProtKB/Swiss-Prot Function]