Mouse Thbd activation kit by CRISPRa

CAT#: GA204333

Thbd CRISPRa kit - CRISPR gene activation of mouse thrombomodulin

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Thbd
• Locus ID: 21824
• Kit Components:

  GA204333G1, Thbd gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204333G2, Thbd gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204333G3, Thbd gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009378
• UniProt ID: P15306
• Synonyms: AI385582; CD141; TM
• Summary: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.[UniProtKB/Swiss-Prot Function]