Mouse Mybbp1a activation kit by CRISPRa

CAT#: GA203075

Mybbp1a CRISPRa kit - CRISPR gene activation of mouse MYB binding protein (P160) 1a

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Mybbp1a
• Locus ID: 18432
• Kit Components:

  GA203075G1, Mybbp1a gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203075G2, Mybbp1a gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203075G3, Mybbp1a gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016776
• UniProt ID: Q7TPV4
• Synonyms: AL024407; AU019902; p67MBP; P160; p160MBP
• Summary: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:9447996, PubMed:11956195, PubMed:14744933). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity).[UniProtKB/Swiss-Prot Function]