Mouse Nup62 activation kit by CRISPRa

CAT#: GA202995

Nup62 CRISPRa kit - CRISPR gene activation of mouse nucleoporin 62

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Nup62
• Locus ID: 18226
• Kit Components:

  GA202995G1, Nup62 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202995G2, Nup62 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202995G3, Nup62 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_053074
• UniProt ID: Q63850
• Synonyms: D7Ertd649e; Nupc1; p62
• Summary: Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.[UniProtKB/Swiss-Prot Function]