Mouse Il4ra activation kit by CRISPRa

CAT#: GA202146

Il4ra CRISPRa kit - CRISPR gene activation of mouse interleukin 4 receptor, alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Il4ra
• Locus ID: 16190
• Kit Components:

  GA202146G1, Il4ra gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202146G2, Il4ra gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202146G3, Il4ra gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001008700, NM_010557, NM_001363983
• UniProt ID: P16382
• Synonyms: CD124; Il4r
• Summary: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.[UniProtKB/Swiss-Prot Function]