Mouse Fkbp8 activation kit by CRISPRa

CAT#: GA201433

Fkbp8 CRISPRa kit - CRISPR gene activation of mouse FK506 binding protein 8

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Fkbp8
• Locus ID: 14232
• Kit Components:

  GA201433G1, Fkbp8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201433G2, Fkbp8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201433G3, Fkbp8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001111066, NM_001199631, NM_010223
• UniProt ID: O35465
• Synonyms: 38kDa; FKBP-8; FKBP-38; Fkbp38
• Summary: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.[UniProtKB/Swiss-Prot Function]