Mouse Dkk1 activation kit by CRISPRa

CAT#: GA201075

Dkk1 CRISPRa kit - CRISPR gene activation of mouse dickkopf WNT signaling pathway inhibitor 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Dkk1
• Locus ID: 13380
• Kit Components:

  GA201075G1, Dkk1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201075G2, Dkk1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201075G3, Dkk1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010051
• UniProt ID: O54908
• Synonyms: mdkk-1
• Summary: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822).[UniProtKB/Swiss-Prot Function]