Human MAP1LC3B2 activation kit by CRISPRa

CAT#: GA118686

MAP1LC3B2 CRISPRa kit - CRISPR gene activation of human microtubule associated protein 1 light chain 3 beta 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MAP1LC3B2
• Locus ID: 643246
• Kit Components:

  GA118686G1, MAP1LC3B2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118686G2, MAP1LC3B2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118686G3, MAP1LC3B2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001085481
• UniProt ID: A6NCE7
• Synonyms: ATG8G
• Summary: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).[UniProtKB/Swiss-Prot Function]