Human PAIP2B activation kit by CRISPRa

CAT#: GA118297

PAIP2B CRISPRa kit - CRISPR gene activation of human poly(A) binding protein interacting protein 2B

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: PAIP2B
• Locus ID: 400961
• Kit Components:

  GA118297G1, PAIP2B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118297G2, PAIP2B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118297G3, PAIP2B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020459
• UniProt ID: Q9ULR5
• Synonyms: KIAA1155
• Summary: Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]