Human NALP6 (NLRP6) activation kit by CRISPRa

CAT#: GA116240

NLRP6 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 6

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NLRP6
• Locus ID: 171389
• Kit Components:

  GA116240G1, NALP6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116240G2, NALP6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116240G3, NALP6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001276700, NM_138329
• UniProt ID: P59044
• Synonyms: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; PAN3; PYPAF5
• Summary: The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]