Human ELAC2 activation kit by CRISPRa

CAT#: GA111867

ELAC2 CRISPRa kit - CRISPR gene activation of human elaC ribonuclease Z 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ELAC2
• Locus ID: 60528
• Kit Components:

  GA111867G1, ELAC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111867G2, ELAC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111867G3, ELAC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001165962, NM_018127, NM_173717
• UniProt ID: Q9BQ52
• Synonyms: COXPD17; ELC2; HPC2
• Summary: The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]