Human Sec8 (EXOC4) activation kit by CRISPRa

CAT#: GA111846

EXOC4 CRISPRa kit - CRISPR gene activation of human exocyst complex component 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: EXOC4
• Locus ID: 60412
• Kit Components:

  GA111846G1, Sec8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111846G2, Sec8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111846G3, Sec8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037126, NM_021807
• UniProt ID: Q96A65
• Synonyms: SEC8; SEC8L1; Sec8p
• Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]