Human RAIN (RASIP1) activation kit by CRISPRa

CAT#: GA110372

RASIP1 CRISPRa kit - CRISPR gene activation of human Ras interacting protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: RASIP1
• Locus ID: 54922
• Kit Components:

  GA110372G1, RAIN gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA110372G2, RAIN gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA110372G3, RAIN gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017805
• UniProt ID: Q5U651
• Synonyms: RAIN
• Summary: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.[UniProtKB/Swiss-Prot Function]