Human IL36 alpha (IL36A) activation kit by CRISPRa

CAT#: GA109054

IL36A CRISPRa kit - CRISPR gene activation of human interleukin 36 alpha

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: IL36A
• Locus ID: 27179
• Kit Components:

  GA109054G1, IL36 alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109054G2, IL36 alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109054G3, IL36 alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014440
• UniProt ID: Q9UHA7
• Synonyms: FIL1; FIL1(EPSILON); FIL1E; IL-1F6; IL1(EPSILON); IL1F6
• Summary: The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]