Human SARM (SARM1) activation kit by CRISPRa

CAT#: GA108037

SARM1 CRISPRa kit - CRISPR gene activation of human sterile alpha and TIR motif containing 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SARM1
• Locus ID: 23098
• Kit Components:

  GA108037G1, SARM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108037G2, SARM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108037G3, SARM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015077
• UniProt ID: Q6SZW1
• Synonyms: MyD88-5; SAMD2; SARM
• Summary: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function]