Human SLC17A4 activation kit by CRISPRa

CAT#: GA106807

SLC17A4 CRISPRa kit - CRISPR gene activation of human solute carrier family 17 member 4

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: SLC17A4
• Locus ID: 10050
• Kit Components:

  GA106807G1, SLC17A4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106807G2, SLC17A4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106807G3, SLC17A4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286121, NM_005495
• UniProt ID: Q9Y2C5
• Synonyms: KAIA2138
• Summary: Phosphate homeostasis is maintained by regulating intake, intestinal absorption, bone deposition and resorption, and renal excretion of phosphate. The central molecule in the control of phosphate excretion from the kidney is the sodium/phosphate cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the renal proximal tubule. NPT1 uses the transmembrane electrochemical potential gradient of sodium to transport phosphate across the cell membrane. SLC17A4 is a similar sodium/phosphate cotransporter in the intestinal mucosa that plays an important role in the absorption of phosphate from the intestine (summary by Shibui et al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011]