Human P4HA2 activation kit by CRISPRa

CAT#: GA105970

P4HA2 CRISPRa kit - CRISPR gene activation of human prolyl 4-hydroxylase subunit alpha 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: P4HA2
• Locus ID: 8974
• Kit Components:

  GA105970G1, P4HA2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105970G2, P4HA2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105970G3, P4HA2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001017973, NM_001017974, NM_001142598, NM_001142599, NM_004199, NM_001365679, NM_001365680, NM_001365681, NM_001365677, NM_001365678
• UniProt ID: O15460
• Synonyms: 4-PH alpha 2
• Summary: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]