Human NUMB activation kit by CRISPRa

CAT#: GA105733

NUMB CRISPRa kit - CRISPR gene activation of human NUMB endocytic adaptor protein

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NUMB
• Locus ID: 8650
• Kit Components:

  GA105733G1, NUMB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105733G2, NUMB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105733G3, NUMB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005743, NM_001005744, NM_001005745, NM_001320114, NM_003744
• UniProt ID: P49757
• Synonyms: C14orf41; c14_5527; S171
• Summary: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]