Human GABA B Receptor 1 (GABBR1) activation kit by CRISPRa

CAT#: GA101694

GABBR1 CRISPRa kit - CRISPR gene activation of human gamma-aminobutyric acid type B receptor subunit 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GABBR1
• Locus ID: 2550
• Kit Components:

  GA101694G1, GABA B Receptor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101694G2, GABA B Receptor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101694G3, GABA B Receptor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319053, NM_001470, NM_021903, NM_021904, NM_021905
• UniProt ID: Q9UBS5
• Synonyms: GABABR1; GABBR1-3; GB1; GPRC3A
• Summary: This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]