Crbn (NM_001015003) Rat Tagged ORF Clone Lentiviral Particle
CAT#: RR203397L3V
- LentiORF®
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Lenti ORF particles, Crbn (Myc-DDK-tagged ORF) - Rat cereblon (Crbn), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
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Specifications
Product Data | |
Type | Rat Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Crbn |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001015003 |
ORF Size | 1335 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RR203397).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001015003.2, NP_001015003.1 |
RefSeq Size | 2257 bp |
RefSeq ORF | 1338 bp |
Locus ID | 297498 |
UniProt ID | Q56AP7 |
Cytogenetics | 4q41 |
Gene Summary | Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.[UniProtKB/Swiss-Prot Function] |
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