FRMD8 (NM_031904) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC207879L3V
- LentiORF®
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Lenti ORF particles, FRMD8 (Myc-DDK tagged) - Human FERM domain containing 8 (FRMD8), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
AAV Particle: DDK
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | FRMD8 |
Synonyms | FKSG44; iTAP |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_031904 |
ORF Size | 1392 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC207879).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_031904.2, NP_114110.1 |
RefSeq Size | 3774 bp |
RefSeq ORF | 1395 bp |
Locus ID | 83786 |
UniProt ID | Q9BZ67 |
Cytogenetics | 11q13.1 |
Domains | B41 |
MW | 51.2 kDa |
Gene Summary | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019).[UniProtKB/Swiss-Prot Function] |
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