Prealbumin (TTR) (NM_000371) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC204976L1V
- LentiORF®
Lenti ORF particles, TTR (Myc-DDK tagged) - Human transthyretin (TTR), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro mGFP mGFP w/ Puro
AAV Particle: DDK
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Prealbumin |
Synonyms | ATTR; CTS; CTS1; HEL111; HsT2651; PALB; TBPA; TTN |
Mammalian Cell Selection | None |
Vector | pLenti-C-Myc-DDK |
ACCN | NM_000371 |
ORF Size | 441 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC204976).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_000371.1 |
RefSeq Size | 938 bp |
RefSeq ORF | 444 bp |
Locus ID | 7276 |
UniProt ID | P02766 |
Cytogenetics | 18q12.1 |
Domains | TR_THY |
Protein Families | ES Cell Differentiation/IPS, Secreted Protein |
MW | 15.9 kDa |
Gene Summary | This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017] |
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