Granulin (GRN) (NM_002087) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC202139L2V
- LentiORF®
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Lenti ORF particles, GRN (mGFP-tagged) - Human granulin (GRN), 200ul, >10^7 TU/mL
Lentiviral Particles: DDK DDK w/ Puro mGFP w/ Puro
Product Images
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Specifications
Product Data | |
Type | Human Tagged ORF Clone Lentiviral Particle |
Tag | mGFP |
Symbol | Granulin |
Synonyms | CLN11; GEP; GP88; PCDGF; PEPI; PGRN |
Mammalian Cell Selection | None |
Vector | pLenti-C-mGFP |
ACCN | NM_002087 |
ORF Size | 1779 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC202139).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_002087.2 |
RefSeq Size | 2323 bp |
RefSeq ORF | 1782 bp |
Locus ID | 2896 |
UniProt ID | P28799 |
Cytogenetics | 17q21.31 |
Domains | GRAN |
Protein Families | Druggable Genome, Secreted Protein |
MW | 63.5 kDa |
Gene Summary | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] |
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