Granulin (GRN) (NM_002087) Human Tagged Lenti ORF Clone
CAT#: RC202139L3
- LentiORF®
Lenti ORF clone of Human granulin (GRN), Myc-DDK-tagged
"NM_002087" in other vectors (7)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | Granulin |
Synonyms | CLN11; GEP; GP88; PCDGF; PEPI; PGRN |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC202139).
|
Restriction Sites | SgfI-MluI Cloning Scheme for this gene |
ACCN | NM_002087 |
ORF Size | 1779 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_002087.2 |
RefSeq Size | 2323 bp |
RefSeq ORF | 1782 bp |
Locus ID | 2896 |
UniProt ID | P28799 |
Cytogenetics | 17q21.31 |
Domains | GRAN |
Protein Families | Druggable Genome, Secreted Protein |
MW | 63.5 kDa |
Gene Summary | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC202139 | GRN (Myc-DDK-tagged)-Human granulin (GRN) |
USD 552.00 |
|
RC202139L1 | Lenti ORF clone of Human granulin (GRN), Myc-DDK-tagged |
USD 852.00 |
|
RC202139L2 | Lenti ORF clone of Human granulin (GRN), mGFP tagged |
USD 852.00 |
|
RC202139L4 | Lenti ORF clone of Human granulin (GRN), mGFP tagged |
USD 852.00 |
|
RG202139 | GRN (tGFP-tagged) - Human granulin (GRN) |
USD 752.00 |
|
SC118822 | GRN (untagged)-Human granulin (GRN) |
USD 553.00 |
|
SC323935 | GRN (untagged)-Human granulin (GRN) |
USD 553.00 |
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