Was (NM_009515) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR226777L3V
- LentiORF®
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Lenti ORF particles, Was (Myc-DDK-tagged) - Mouse Wiskott-Aldrich syndrome homolog (human) (Was), 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
AAV Particle: DDK
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Product Images
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Specifications
Product Data | |
Type | Mouse Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Was |
Synonyms | U42471; Wasp |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_009515 |
ORF Size | 1560 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR226777).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_009515.2, NP_033541.1 |
RefSeq Size | 2094 bp |
RefSeq ORF | 1563 bp |
Locus ID | 22376 |
UniProt ID | P70315 |
Cytogenetics | X 3.65 cM |
Gene Summary | Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).[UniProtKB/Swiss-Prot Function] |
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