Sin3b (NM_009188) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR220995L3V

Lenti ORF particles, Sin3b (Myc-DDK-tagged) - Mouse transcriptional regulator, SIN3B (yeast) (Sin3b), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Sin3b
• Synonyms: 2810430C10Rik
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_009188
• ORF Size: 3294 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR220995).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_009188.3, NP_033214.2
• RefSeq Size: 4117 bp
• RefSeq ORF: 3297 bp
• Locus ID: 20467
• UniProt ID: Q62141
• Cytogenetics: 8 35.08 cM
• Gene Summary: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).[UniProtKB/Swiss-Prot Function]