Rpa1 (NM_026653) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR209516L3V
- LentiORF®
Lenti ORF particles, Rpa1 (Myc-DDK-tagged) - Mouse replication protein A1 (Rpa1), transcript variant 2, 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
Interest in protein/lysate? Submit request here!
Product Images
Frequently bought together (2)
Other products for "Rpa1"
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone Lentiviral Particle |
Tag | Myc-DDK |
Symbol | Rpa1 |
Synonyms | 70kDa; 5031405K23Rik; AA589576; AW557552; RF-A; RP-A; Rpa |
Mammalian Cell Selection | Puromycin |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_026653 |
ORF Size | 1872 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR209516).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_026653.1, NP_080929.1 |
RefSeq Size | 3058 bp |
RefSeq ORF | 1872 bp |
Locus ID | 68275 |
UniProt ID | Q8VEE4 |
Cytogenetics | 11 45.79 cM |
Gene Summary | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.