Wipi2 (NM_178398) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR207108L4V

Lenti ORF particles, Wipi2 (GFP-tagged) - Mouse WD repeat domain, phosphoinositide interacting 2 (Wipi2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Wipi2
• Synonyms: 1110018O08Rik; 2510001I10Rik
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_178398
• ORF Size: 1338 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR207108).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_178398.2, NP_848485.1
• RefSeq Size: 3913 bp
• RefSeq ORF: 1338 bp
• Locus ID: 74781
• UniProt ID: Q80W47
• Cytogenetics: 5 G2
• Gene Summary: Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.[UniProtKB/Swiss-Prot Function]